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No, if three vectors do not lie in a plane, they cannot give zero resultant.

Explanation:

Let A, B and C be three vectors. If they give zero resultant, then

     A+B+C=0

or, A= -(B+C)

Hence, they will produce zero resultant, if A is equal to negative of vector (B+C). The vector (B+C) lies in the plane of B and C. Hence, A will be equal to negative of (B+C) if A, B and C all lie in a plane.